Potassium Carbonate → HCID 57541276, compound

HRID 1677043Notes

Reaction equation

HRID 1677043 reaction equation
Cl.Cl[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[C:11]([C:13]1([NH:16][C:17]([C@@H:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C@H:20]2[C:25]([N:27]2[CH2:40][CH2:39][C:30]3[NH:31][C:32]4[C:33]([OH:38])=[CH:34][CH:35]=[CH:36][C:37]=4[C:29]=3[CH2:28]2)=[O:26])=[O:18])[CH2:15][CH2:14]1)#[N:12].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:11]([C:13]1([NH:16][C:17]([C@@H:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C@H:20]2[C:25]([N:27]2[CH2:40][CH2:39][C:30]3[NH:31][C:32]4[C:33]([O:38][CH2:3][CH2:4][N:5]5[CH2:10][CH2:9][O:8][CH2:7][CH2:6]5)=[CH:34][CH:35]=[CH:36][C:37]=4[C:29]=3[CH2:28]2)=[O:26])=[O:18])[CH2:15][CH2:14]1)#[N:12]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 25142825HCID 25142825, compound

Product 1

HCID 57541276HCID 57541276, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following on from Example 34, 4-(2-Chloroethyl)morpholine hydrochloride (90 mg, 0.48 mmol) was added to (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-hydroxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (131 mg, 0.32 mmol) and potassium carbonate (134 mg, 0.97 mmol) in DMF (5 ml) at 25° C. under air. The resulting solution was stirred at room temperature for 45 hours, to yield after purification a cream solid. (4.00 mg, 2.4%).

Workup

  1. customto yield
  2. customafter purification a cream solid

Sources & evidence

ORD record
ord-831883306a7040f1b1f3eea230f0725e
Source dataset
uspto-grants-2011_08
Patent number
US08008279B2

Reaction notes

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