反应详情

4 N hydrochloric acid/ethyl acetate (26.8 mL) was added to an ethyl acetate (20 mL) solution of (S)-2-((R)-1-hydroxyethyl)-5-(3,4,5-trifluorophenyl)pyrrolidine-1-carboxylic acid t-butyl ester (3.71 g), and stirring was continued for 2 hours at room temperature. The solvent was removed under a vacuum, and 5 N sodium hydroxide solution and dichloromethane were added, and the organic layer was partitioned. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed under a vacuum, and the title compound (2.6 g) was obtained. The physical property values are as follows.

1. customThe solvent was removed under a vacuum, and 5 N sodium hydroxide solution and dichloromethane
2. additionwere added
3. customthe organic layer was partitioned
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. customthe solvent was removed under a vacuum