2-(4-Biphenyl)ethylamine → HCID 57571686, compound

HRID 1677118Notes

Reaction equation

HRID 1677118 reaction equation
CO[C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][C:5]=1Cl.[N:12]1([CH2:18][CH2:19][CH2:20][NH2:21])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[C:22]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][NH2:30])=[CH:24][CH:23]=1>>[C:22]1([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:23]=[CH:24][C:25]([CH2:28][CH2:29][NH:30][C:3](=[O:11])[C:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=2[NH:21][CH2:20][CH2:19][CH2:18][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 282102-(4-Biphenyl)ethylamineHCID 61055N-(3-Aminopropyl)morpholineHCID 819931Methyl 2-chloronicotinate

Product 1

HCID 57571686HCID 57571686, compound

Procedure

The title compound was prepared in analogy to example 1, but starting from 2-chloro-nicotinic acid methyl ester and subsequently using 3-morpholin-4-yl-propylamine in the first step and 2-biphenyl-4-yl-ethylamine in the third step.

Sources & evidence

ORD record
ord-9abb823d192f4ff6b93cb0053d4e6f50
Source dataset
uspto-grants-2011_08
Patent number
US08008305B2

Reaction notes

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