Hexane → HCID 178519486, compound

HRID 1677122Notes

Reaction equation

HRID 1677122 reaction equation
[C:1]([C:9](=[CH:15][NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[C:23]([F:26])([F:25])[F:24])[C:10](OCC)=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCCCCC>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[OH:11][C:10]1[C:22]2[C:17](=[C:18]([C:23]([F:24])([F:26])[F:25])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][C:9]=1[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]

Participants

4

Reactant 2

HCID 8058HexaneHCID 178471912HCID 178471912, compound

Product 1

HCID 178519486HCID 178519486, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Procedure

A solution of ethyl 2-benzoyl-3-[2-(trifluoromethyl)phenylamino]acrylate (30.5 g, 84.0 mmol) in Dowtherm® (280 mL) was stirred at 260° C. for 11 hours. The reaction solution was returned to room temperature, then added with hexane and recrystallized. The title compound (17.0 g, yield 64%) was obtained as a brown oil.

Workup

  1. customwas returned to room temperature
  2. customrecrystallized

Sources & evidence

ORD record
ord-4be2271abe41401688a1a7c8791a7a28
Source dataset
uspto-grants-2011_08
Patent number
US08008306B2

Reaction notes

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