2-Methoxypyrimidine-5-boronic acid → HCID 57980028, compound

HRID 1677165Notes

Reaction equation

HRID 1677165 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C@H:12]2[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:10])=[C:4]([F:22])[CH:3]=1.[CH3:23][O:24][C:25]1[N:30]=[CH:29][C:28](B(O)O)=[CH:27][N:26]=1>>[F:8][C:6]1[CH:7]=[C:2]([C:28]2[CH:27]=[N:26][C:25]([O:24][CH3:23])=[N:30][CH:29]=2)[CH:3]=[C:4]([F:22])[C:5]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:10]

Participants

3

Reactant 2

HCID 27367782-Methoxypyrimidine-5-boronic acidHCID 11965202HCID 11965202, compound

Product 1

HCID 57980028HCID 57980028, compound

Procedure

The title compound is prepared in a manner substantially analogous to Example 14 via Procedure F′ from (4-bromo-2,6-difluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 2-methoxypyrimidine-5-boronic acid (CAS 628692-15-9). MS (FIA) 403 (MH+)

Sources & evidence

ORD record
ord-55a100e6d0a5491f8c8b72e7db813c84
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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