Prolinol, (R)- → HCID 57980097, compound

HRID 1677192Notes

Reaction equation

HRID 1677192 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15](O)=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[Li].[NH:21]1[CH2:25][CH2:24][CH2:23][C@@H:22]1[CH2:26][OH:27]>>[OH:27][CH2:26][C@H:22]1[CH2:23][CH2:24][CH2:25][N:21]1[C:15]([C:12]1[CH:11]=[CH:10][C:9]([C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:18])([F:1])[F:19])=[CH:8][CH:7]=2)=[CH:14][CH:13]=1)=[O:16]

Participants

4

Reactant 3

HCID 2724541Prolinol, (R)-HCID 27827194'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acidHCID 3028194Lithium

Product 1

HCID 57980097HCID 57980097, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure B′ from 4′-trifluoromethyl-biphenyl-4-carboxylic acid, lithium salt using (R)-2-pyrrolidine methanol as the amine. MS (ES+) 350.2

Sources & evidence

ORD record
ord-55ec914f5b5d4d6aa93d3ee10fb51cf6
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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