Pyrrolidine → HCID 57980139, compound

HRID 1677193Notes

Reaction equation

HRID 1677193 reaction equation
O[CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:9].[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[N:26]1([CH2:2][C@H:3]2[CH2:7][CH2:6][CH2:5][N:4]2[C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)=[O:9])[CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 57980097HCID 57980097, compound

Product 1

HCID 57980139HCID 57980139, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure RR starting from (2-(R)-hydroxymethyl-pyrrolidin-1-yl)-(4′-trifluoromethyl-biphenyl-4-yl)-methanone and pyrrolidine. MS (M+H) 403.2

Sources & evidence

ORD record
ord-c97f1674542741f597d19b9f3cdaa689
Source dataset
uspto-grants-2011_08
Patent number
US08008301B2

Reaction notes

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