HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (2-hydroxy-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid | HCID 59540796 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (2-hydroxy-propyl)-amide | HCID 44206947 | — |
Reaction Steps
2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (2-hydroxy-propyl)-amide was prepared starting from 2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid and 1-amino-propan-2-ol following the general procedures described in these Examples but with DMF as solvent. MP 201.9-202.6° C., M+H 387.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008298B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-26eb576affe84aae9130041b8ece463e |
| Source note | uspto-grants-2011_08 |