1-Amino-2-propanol → 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (2-hydroxy-propyl)-amide

HRID 1677372Notes

Reaction equation

HRID 1677372 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[N:14]=[C:15]3[C:21]([C:22](O)=[O:23])=[CH:20][NH:19][C:16]3=[N:17][CH:18]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[NH2:25][CH2:26][CH:27]([OH:29])[CH3:28]>CN(C=O)C>[OH:29][CH:27]([CH3:28])[CH2:26][NH:25][C:22]([C:21]1[C:15]2[C:16](=[N:17][CH:18]=[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[N:14]=2)[NH:19][CH:20]=1)=[O:23]

Participants

4

Reactant 2

HCID 41-Amino-2-propanolHCID 595407962-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

Product 1

HCID 442069472-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (2-hydroxy-propyl)-amide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (2-hydroxy-propyl)-amide was prepared starting from 2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid and 1-amino-propan-2-ol following the general procedures described in these Examples but with DMF as solvent. MP 201.9-202.6° C., M+H 387.

Sources & evidence

ORD record
ord-26eb576affe84aae9130041b8ece463e
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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