7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine → 3-Methoxy-2,2-dimethyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one

HRID 1677439Notes

Reaction equation

HRID 1677439 reaction equation
I[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=3)[N:9]=2)[N:4]([Si](C(C)C)(C(C)C)C(C)C)[CH:3]=1.[CH3:33][O:34][CH2:35][C:36]([CH3:44])([CH3:43])[C:37](N(OC)C)=[O:38]>>[CH3:33][O:34][CH2:35][C:36]([CH3:44])([CH3:43])[C:37]([C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=3)[N:9]=2)[NH:4][CH:3]=1)=[O:38]

Participants

3

Reactant 2

HCID 595405257-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazineHCID 86646688HCID 86646688, compound

Product 1

HCID 595407753-Methoxy-2,2-dimethyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one

Procedure

3-Methoxy-2,2-dimethyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one was prepared starting from 7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine and 3,N-dimethoxy-2,2,N-trimethyl-propionamide following general procedures as described in these Examples, to afford a pale yellow solid. M+H=400.

Workup

  1. customto afford a pale yellow solid

Sources & evidence

ORD record
ord-ee6e1c5d12b84f7583a312eca962eb00
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

Loading…