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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1677439Generated: October 30, 2026

7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine → 3-Methoxy-2,2-dimethyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one

https://huagongshe.com/reaction/1677439

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazineHCID 59540525—
ReactantHCID 86646688HCID 86646688—
Product3-Methoxy-2,2-dimethyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-oneHCID 59540775—

Reaction Steps

3-Methoxy-2,2-dimethyl-1-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one was prepared starting from 7-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine and 3,N-dimethoxy-2,2,N-trimethyl-propionamide following general procedures as described in these Examples, to afford a pale yellow solid. M+H=400.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08008298B2
Source datasetuspto-grants-2011_08
ORD IDord-ee6e1c5d12b84f7583a312eca962eb00
Source noteuspto-grants-2011_08