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HRID1677443

反应详情

EQUATION

反应方程式

HRID 1677443 的结构方程式

REACTANTS

反应物

2
结构：CCCOc1cccc(B(O)O)c1
HCID3691230

3-Propoxyphenylboronic acid

C9H13BO3

结构：CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12
HCID57829218

1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

C11H12BrN3O

PRODUCTS

生成物

1
结构：CCCOc1cccc(-c2cnc3[nH]cc(C(=O)C(C)(C)C)c3n2)c1
HCID59540536

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2,2-Dimethyl-1-[2-(3-propoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and 3-propyloxybenzene boronic acid following general procedures as described in these Examples. Silica gel chromatography using 30-70% EtOAc in hexanes as eluant provided 56 mg (38%) of a yellow solid. MP 179-180° C., M+H=338.