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HRID1677448

反应详情

EQUATION

反应方程式

HRID 1677448 的结构方程式

REACTANTS

反应物

2
结构：NS(=O)(=O)c1cccc(B(O)O)c1
HCID44119323

(3-Sulfamoylphenyl)boronic acid

C6H8BNO4S

结构：CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12
HCID57829218

1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

C11H12BrN3O

PRODUCTS

生成物

1
结构：CC(C)(C)C(=O)c1c[nH]c2ncc(-c3cccc(S(N)(=O)=O)c3)nc12
HCID59540638

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

3-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-benzenesulfonamide was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and (3-aminosulfonylphenyl)Boronic Acid following general procedures as described in these Examples. Silica gel chromatography using 20-100% EtOAc in hexanes as eluant provided 60 mg (37%) of a pale yellow solid. MP 275-277° C., M+H=359.