反应详情

(1-Methyl-cyclopentyl)-[2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone was prepared starting from (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclopentyl)-methanone and 3,4,5-trimethoxyphenylboronic acid following general procedures as described in these Examples. Silica gel chromatography using 2-50% EtOAc in hexanes as eluant gave a pale brown solid which was washed with 1:1 Et2O/Hexanes provided 10 mg (7.7%) of an off white solid. MP 244-246° C., M+H=396.

1. customgave a pale brown solid which
2. washwas washed with 1:1 Et2O/Hexanes
3. customprovided 10 mg (7.7%) of an off white solid