HRID1677453

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID14923

Ammonium hydroxide

H5NO

HCID16427085

[3-(Aminomethyl)phenyl]boronic acid--hydrogen chloride (1/1)

C7H11BClNO2

反应SMILES：CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12

HCID57829218

1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

C11H12BrN3O

PRODUCTS

产物

反应SMILES：CC(C)(C)C(=O)c1c[nH]c2ncc(-c3cccc(CN)c3)nc12

HCID59540591

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

1-[2-(3-Aminomethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and (3-aminomethylphenyl)boronic acid hydrochloride following general procedures as described in these Examples. Silica gel chromatography using 0-20% [5% NH4OH:MeOH]/DCM as eluant gave a brown solid which was washed with 1:2 Et2O/Hexanes to provide 75 mg (48%) of a pale brown solid. MP 176-178° C., M+H=309.

WORKUP

后处理

customgave a brown solid which
washwas washed with 1:2 Et2O/Hexanes