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HRID1677454

反应详情

EQUATION

反应方程式

HRID 1677454 的结构方程式

REACTANTS

反应物

4
结构：CO
HCID887

Methanol

CH4O

结构：[NH4+].[OH-]
HCID14923

Ammonium hydroxide

H5NO

结构：Cl.OB(O)c1cccc(CN2CCCCC2)c1
HCID46738812

{3-[(Piperidin-1-yl)methyl]phenyl}boronic acid--hydrogen chloride (1/1)

C12H19BClNO2

结构：CC(C)(C)C(=O)c1c[nH]c2ncc(Br)nc12
HCID57829218

1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

C11H12BrN3O

PRODUCTS

生成物

1
结构：CC(C)(C)C(=O)c1c[nH]c2ncc(-c3cccc(CN4CCCCC4)c3)nc12
HCID59541032

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

2,2-Dimethyl-1-[2-(3-piperidin-1-ylmethyl-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and 3-(piperidin-1-ylmethyl)phenylboronic acid hydrochloride following general procedures as described in these Examples. Silica gel chromatography using 0-20% [5% NH4OH:MeOH]/DCM as eluant gave a brown solid which was washed with 1:2 Et2O/Hexanes to provide 70 mg (36%) of a pale brown solid. MP 176-177° C., M+H=377.

WORKUP

后处理

  1. customgave a brown solid which
  2. washwas washed with 1:2 Et2O/Hexanes