3-Fluorophenylboronic acid → HCID 59541060, compound

HRID 1677455Notes

Reaction equation

HRID 1677455 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[F:17][C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=1>CCOC(C)=O>[F:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=1[C:2]1[N:3]=[C:4]2[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 578292181-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Product 1

HCID 59541060HCID 59541060, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-[2-(2-Fluoro-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and 3-fluorobenzeneboronic acid following general procedures as described in these Examples. Silica gel chromatography using 20-100% EtOAc in hexanes as eluant gave a brown solid which was washed with 1:1 Et2O/Hexanes to provide 10 mg (12%) of a pale yellow solid. M+H=298.

Workup

  1. customgave a brown solid which
  2. washwas washed with 1:1 Et2O/Hexanes

Sources & evidence

ORD record
ord-4fa4a998a2e04eeda617ae4ce6ad312a
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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