1-Adamantanecarbonyl chloride → Adamantan-1-yl-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone

HRID 1677466Notes

Reaction equation

HRID 1677466 reaction equation
[Br:1][C:2]1[N:3]=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[C:11]12([C:21](Cl)=[O:22])[CH2:20][CH:15]3[CH2:16][CH:17]([CH2:19][CH:13]([CH2:14]3)[CH2:12]1)[CH2:18]2>>[C:11]12([C:21]([C:10]3[C:4]4[C:5](=[N:6][CH:7]=[C:2]([Br:1])[N:3]=4)[NH:8][CH:9]=3)=[O:22])[CH2:18][CH:17]3[CH2:16][CH:15]([CH2:14][CH:13]([CH2:19]3)[CH2:12]1)[CH2:20]2

Participants

3

Reactant 2

HCID 989151-Adamantanecarbonyl chlorideHCID 250673082-bromo-5H-pyrrolo[2,3-b]pyrazine

Product 1

HCID 44182410Adamantan-1-yl-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone

Procedure

Adamantan-1-yl-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone was prepared starting from 2-bromo-5H-pyrrolo[2,3-b]pyrazine and adamantane-1-carbonyl chloride following general procedures as described in these Examples. MP 279-280° C., M+H=360.

Sources & evidence

ORD record
ord-7c44bc719ca64c259966457955decaf9
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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