HCID 67345820, compound → HCID 59540932, compound

HRID 1677503Notes

Reaction equation

HRID 1677503 reaction equation
[CH3:1][O:2][CH2:3][C:4]1([CH3:38])[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([C:15]3[N:16]=[C:17]4[C:23]([C:24](=[O:29])[C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:22][N:21](COCC[Si](C)(C)C)[C:18]4=[N:19][CH:20]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:5]1>C(Cl)Cl.CO>[CH3:1][O:2][CH2:3][C:4]1([CH3:38])[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([C:15]3[N:16]=[C:17]4[C:23]([C:24](=[O:29])[C:25]([CH3:27])([CH3:26])[CH3:28])=[CH:22][NH:21][C:18]4=[N:19][CH:20]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:5]1

Participants

3

Reactant 1

HCID 67345820HCID 67345820, compound

Product 1

HCID 59540932HCID 59540932, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

1-{2-[3-(3-Methoxymethyl-3-methyl-pyrrolidin-1-yl)-phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl}-2,2-dimethyl-propan-1-one was prepared following the same procedure using 1-[2-[3-(3-Methoxymethyl-3-methyl-pyrrolidin-1-yl)-phenyl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one as starting material. The product was obtained in 50% yield by SiO2 chromatography (DCM/MeOH 0-5% MeOH).

Sources & evidence

ORD record
ord-49fdfe94435445c29d8afdec4da7c3dc
Source dataset
uspto-grants-2011_08
Patent number
US08008298B2

Reaction notes

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