反应详情

温度

100 °C

In a flask N-(4-{3-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-phenylsulfamoyl}-phenyl)-acetamide 0.034 gm (0.069 mM), 1 ml water and 10 drops 3M aqueous sodium hydroxide was added and the mixture heated to 100° C. for two hours. Water (20 ml) was added and the pH adjusted to 8 with hydrochloric acid and much solid formed. The mixture was extracted three times with ethyl acetate, the ethyl acetate dried over magnesium sulfate to give 4-Amino-N-{3-[7-(2,2-dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-phenyl}-benzenesulfonamide 0.023 gm (0.051 mM, 74% yield) M+1 450 m.p. 285-286° C.

1. customformed
2. extractionThe mixture was extracted three times with ethyl acetate
3. dry with materialthe ethyl acetate dried over magnesium sulfate