反应详情

Oxalyl chloride (0.39 mL, 4.5 mmol) was added to a 0-5° C. solution of 5-cyano-2,2-dimethyl-pentanoic acid (0.462 g, 2.98 mmol) in 3 mL of dichloromethane, and the mixture was stirred for 3 h then concentrated to afford crude 5-cyano-2,2-dimethyl-pentanoyl chloride as a yellow oil, which was immediately used in the next step.

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