Formic Acid → 8-(Benzyloxy)imidazo[1,5-a]pyridine

HRID 1677560Notes

Reaction equation

HRID 1677560 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([CH2:15][NH2:16])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.[CH:22](O)=O>>[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:22]=[N:16][CH:15]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 284Formic AcidHCID 24813Phosphorus oxychlorideHCID 12074949HCID 12074949, compound

Product 1

HCID 454896908-(Benzyloxy)imidazo[1,5-a]pyridine

Procedure

This compound is prepared according to the same procedure as in preparation II (stage C) from 2.8 g (13.25 mmol) of 1-[3-(benzyloxy)pyridin-2-yl]methanamine [described in Inorg. Chem., (2003), 42(14), 4401] by formylation with formic acid and then cyclization by reaction with phosphoryl chloride. 1.74 g of a brown oil are obtained.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-3acff490c0c045af882b99f14134262e
Source dataset
uspto-grants-2011_08
Patent number
US08008321B2

Reaction notes

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