Sodium Hydroxide → HCID 67215467, compound

HRID 1677590Notes

Reaction equation

HRID 1677590 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][C:29]=1[NH:30][C:31](=[O:34])[CH2:32][CH3:33])[C:6]([C:8]1[N:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]2=[C:10]([C:17]2[CH:18]=[C:19]([CH:24]=[CH:25][CH:26]=2)[C:20]([O:22]C)=[O:21])[N:9]=1)=[O:7].[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][C:29]=1[NH:30][C:31](=[O:34])[CH2:32][CH3:33])[C:6]([C:8]1[N:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]2=[C:10]([C:17]2[CH:18]=[C:19]([CH:24]=[CH:25][CH:26]=2)[C:20]([OH:22])=[O:21])[N:9]=1)=[O:7]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 67215737HCID 67215737, compound

Product 1

HCID 67215467HCID 67215467, compound

Procedure

The compound is obtained by operating according to the preparation described in example 195 by saponification of methyl 3-{3-[3-methoxy-4-[propionylamino]benzoyl]-imidazo[1,5-a]pyridin-1-yl}benzoate obtained in example 191 with 1N sodium hydroxide solution. A yellow solid is collected, which solid is salified in the sodium salt.2.4H2O form. Melting point: 145° C.; 1H NMR (d6-DMSO): 1.08-1.24 (3H, t), 2.46-2.51 (2H, m), 4.03 (3H, s), 7.30-7.55 (3H, m), 7.88-8.38 (6H, m), 8.43 (1H, m), 8.60 (1H, m), 9.40 (1H, m), 9.45 (1H, m), 9.95 (1H, m)

Workup

  1. customThe compound is obtained
  2. customA yellow solid is collected
  3. customform

Sources & evidence

ORD record
ord-c3a5bff94be24ce8bd5d1aa53fc9af79
Source dataset
uspto-grants-2011_08
Patent number
US08008321B2

Reaction notes

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