Sodium Hydroxide → HCID 67215467, compound

Participants

Reaction Steps

The compound is obtained by operating according to the preparation described in example 195 by saponification of methyl 3-{3-[3-methoxy-4-[propionylamino]benzoyl]-imidazo[1,5-a]pyridin-1-yl}benzoate obtained in example 191 with 1N sodium hydroxide solution. A yellow solid is collected, which solid is salified in the sodium salt.2.4H2O form. Melting point: 145° C.; 1H NMR (d6-DMSO): 1.08-1.24 (3H, t), 2.46-2.51 (2H, m), 4.03 (3H, s), 7.30-7.55 (3H, m), 7.88-8.38 (6H, m), 8.43 (1H, m), 8.60 (1H, m), 9.40 (1H, m), 9.45 (1H, m), 9.95 (1H, m)

Provenance & Evidence