Hydrochloric Acid → HCID 67374343, compound

HRID 1677600Notes

Reaction equation

HRID 1677600 reaction equation
C([O:3][C:4](=[O:23])[C:5]([CH:7]1[CH2:12][CH2:11][N:10](C(OCC2C=CC=CC=2)=O)[CH2:9][CH2:8]1)=[CH2:6])C.Cl>O1CCOCC1>[NH:10]1[CH2:11][CH2:12][CH:7]([C:5](=[CH2:6])[C:4]([OH:23])=[O:3])[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67375444HCID 67375444, compound

Product 1

HCID 67374343HCID 67374343, compoundYield 115.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 2-(1-benzyloxycarbonylpiperidin-4-yl)prop-2-enoic acid ethyl ester (0.40 g, 1.4 mmol) in 1 mL of dioxane was added 5 mL of 6 N HCl. The solution was heated to 100° C. for 18 hours. The reaction mixture was evaporated in vacuo to afford 2-(piperidin-4-yl)prop-2-enoic acid (0.25 g, 100%) as a hydrogen chloride salt.

Workup

  1. customThe reaction mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-1ecbea75778d4a70b9bec58ca00cb118
Source dataset
uspto-grants-2011_08
Patent number
US08008325B2

Reaction notes

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