Hydrazine hydrate (1:1) → HCID 58380765, compound

HRID 1677632Notes

Reaction equation

HRID 1677632 reaction equation
F[C:2]1[N:9]=[CH:8][CH:7]=[C:6]([I:10])[C:3]=1[C:4]#[N:5].O.[NH2:12][NH2:13]>CO>[NH:12]([C:2]1[N:9]=[CH:8][CH:7]=[C:6]([I:10])[C:3]=1[C:4]#[N:5])[NH2:13]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58380755HCID 58380755, compound

Product 1

HCID 58380765HCID 58380765, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of 1.2 g of 2-fluoro-4-iodonicotinonitrile in 20 mL of MeOH at 20° C. are added 2.4 mL of hydrazine hydrate. The yellow suspension is stirred for 20 minutes at 20° C. and is then filtered. The precipitate is washed with methanol to give, after drying under vacuum, 947 mg of a white powder of 2-hydrazino-4-iodonicotinonitrile.

Workup

  1. filtrationis then filtered
  2. washThe precipitate is washed with methanol
  3. customto give
  4. dry with materialafter drying under vacuum, 947 mg of a white powder of 2-hydrazino-4-iodonicotinonitrile

Sources & evidence

ORD record
ord-bb4965892c9f48e28dd5111e73acbcc3
Source dataset
uspto-grants-2011_08
Patent number
US08008322B2

Reaction notes

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