HCID 67329712, compound → 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyrid-4-yl)phenyl]-3-(2-ethoxy-5-trifluoromethylphenyl)urea

HRID 1677642Notes

Reaction equation

HRID 1677642 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[NH:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][C:21](B2OC(C)(C)C(C)(C)O2)=[CH:20][CH:19]=1)=[O:16])[CH3:2].I[C:34]1[CH:39]=[CH:38][N:37]=[C:36]2[NH:40][N:41]=[C:42]([NH2:43])[C:35]=12>>[NH2:43][C:42]1[C:35]2[C:36](=[N:37][CH:38]=[CH:39][C:34]=2[C:21]2[CH:22]=[CH:23][C:18]([NH:17][C:15]([NH:14][C:5]3[CH:6]=[C:7]([C:10]([F:11])([F:13])[F:12])[CH:8]=[CH:9][C:4]=3[O:3][CH2:1][CH3:2])=[O:16])=[CH:19][CH:20]=2)[NH:40][N:41]=1

Participants

3

Reactant 2

HCID 67329712HCID 67329712, compoundHCID 1785092294-Iodo-1H-pyrazolo[3,4-b]pyridin-3-amine

Product 1

HCID 1784665601-[4-(3-amino-1H-pyrazolo[3,4-b]pyrid-4-yl)phenyl]-3-(2-ethoxy-5-trifluoromethylphenyl)urea

Procedure

1-(2-Ethoxy-5-trifluoromethylphenyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea is coupled, by Suzuki reaction, with 4-iodo-1H-pyrazolo[3,4-b]pyrid-3-ylamine according to the preparation of Example 6. A yellow powder of 1-[4-(3-amino-1H-pyrazolo[3,4-b]pyrid-4-yl)phenyl]-3-(2-ethoxy-5-trifluoromethylphenyl)urea is obtained, the characteristics of which are as follows:

Sources & evidence

ORD record
ord-97f97df187f1450d84bf84d33e5e023b
Source dataset
uspto-grants-2011_08
Patent number
US08008322B2

Reaction notes

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