Hydrochloric Acid → HCID 67235394, compound

HRID 1677725Notes

Reaction equation

HRID 1677725 reaction equation
[C@@H:1]12[CH2:7][CH2:6][C@@H:5]1[CH2:4][N:3]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18]C)=[O:17])=[CH:14][CH:13]=1)[CH2:2]2.[OH-].[Na+].Cl>CO>[C@@H:5]12[CH2:6][CH2:7][C@@H:1]1[CH2:2][N:3]([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:20][CH:21]=1)[CH2:4]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67235164HCID 67235164, compound

Product 1

HCID 67235394HCID 67235394, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.5 g of the compound of Step 1, of 12.7 ml of 2N sodium hydroxide solution and 8 ml of methanol is heated at reflux for one hour. To the reaction mixture, cooled in an ice bath, there are added 12.7 ml of 2N HCl. The precipitate is washed with water and dried in vacuo.

Workup

  1. temperatureat reflux for one hour
  2. temperatureTo the reaction mixture, cooled in an ice bath
  3. washThe precipitate is washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-915426d21f9242eab1e4ff560d5b8701
Source dataset
uspto-grants-2011_08
Patent number
US08008337B2

Reaction notes

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