HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate | HCID 11992900 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochloride | HCID 67333109 | 93% |
Reaction Steps
A solution of tert-butyl 4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (5 g) in a 2M solution of HCl in ether (100 mL) was stirred at RT for 6 hours. The solvent was removed under vacuum to afford 4.3 g (93%) of the title compound as a solid. TLC—Chloroform/methanol (8/2): Rf=0.2. HPLC purity: 97%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008302B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cdc7ecaeeaae4a48bcad63d5e6449236 |
| Source note | uspto-grants-2011_08 |