反应详情

温度

55 °C

Add to ethyl indole-2-carboxylate 1 (42.3 mmol) in MeOH (50 mL), K2CO3 (1.20 equiv., 50.7 mmol) and stir the suspension with heating to 55° C. for 1 h. Monitor the reaction by tlc (ether/heptane) and when complete concentrate the reaction in vacuo, dilute with H2O and stir for 15 min. Collect the solid by filtration and dry under vacuum at 65° C. for 3 h to afford methyl indole-2-carboxylate 2.

1. concentrationcomplete concentrate
2. customthe reaction in vacuo
3. stirringstir for 15 min
4. customCollect the solid
5. filtrationby filtration
6. customdry under vacuum at 65° C. for 3 h