(R)-2-Tosyloxypropionic acid methyl ester → methyl (2S)-2-({3',5-difluoro-4'-[(3-fluorophenyl)sulfonyl]biphenyl-2-yl}oxy)propanoate

HRID 1677882Notes

Reaction equation

HRID 1677882 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:18]2[C:19]([OH:25])=[CH:20][CH:21]=[C:22]([F:24])[CH:23]=2)[CH:5]=[CH:6][C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=1)(=[O:10])=[O:9].CC1C=CC(S(O[C@H:37]([CH3:42])[C:38]([O:40][CH3:41])=[O:39])(=O)=O)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25][C@@H:37]([CH3:42])[C:38]([O:40][CH3:41])=[O:39])[CH:5]=[CH:6][C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 12884153(R)-2-Tosyloxypropionic acid methyl esterHCID 672385603',5-Difluoro-4'-[(3-fluorophenyl)sulfonyl]biphenyl-2-ol

Product 1

HCID 67239694methyl (2S)-2-({3',5-difluoro-4'-[(3-fluorophenyl)sulfonyl]biphenyl-2-yl}oxy)propanoate

Procedure

The subtitle compound was prepared by the method of example 11 step (vii) using the product of step (iv) and the product of example 11 step (vi).

Sources & evidence

ORD record
ord-803ecde1571c423d99e499a501b14e8c
Source dataset
uspto-grants-2011_08
Patent number
US08008350B2

Reaction notes

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