Ethanol → HCID 59745701, compound

HRID 1677900Notes

Reaction equation

HRID 1677900 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]([F:16])([F:15])[F:14].[S:17]([O-:20])([O-:19])=[O:18].[Na+].[Na+].C(O)C>O>[F:14][C:13]([F:16])([F:15])[O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][S:17]([OH:20])(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 702EthanolHCID 24437Sodium SulfiteHCID 59745710HCID 59745710, compound

Product 1

HCID 59745701HCID 59745701, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6.8 g of bromide from Example 5b (22.35 mmol) and 3.7 g (29 mmol; 1.3 eq) of sodium sulfite are dissolved in 40 ml of deionised water and 40 ml of ethanol in a 250 ml one-necked flask, and the mixture is heated at 100° C. for 20 h. The cooled reaction mixture is extracted with methyl t-butyl ether/heptane (1:1). The aqueous phase is acidified (pH=0) and extracted with methyl t-butyl ether. The combined organic phases are dried over sodium sulfate and evaporated.

Workup

  1. customThe cooled reaction mixture
  2. extractionis extracted with methyl t-butyl ether/heptane (1:1)
  3. extractionextracted with methyl t-butyl ether
  4. dry with materialThe combined organic phases are dried over sodium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-064b227a01b8405d99d303353be99480
Source dataset
uspto-grants-2011_08
Patent number
US08008358B2

Reaction notes

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