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HRID1677984

反应详情

EQUATION

反应方程式

HRID 1677984 的结构方程式

REACTANTS

反应物

2
结构：CO
HCID887

Methanol

CH4O

结构：CC(C)(C)[Si](C)(C)O[C@H]1C[C@@H](OS(C)(=O)=O)C[C@H]1COCc1ccccc1
HCID86618711

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)O[C@H]1C[C@@H](OS(C)(=O)=O)C[C@H]1CO
HCID86618728

(1S,2S,4S)-2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-4-[(methylsulfonyl)oxy]cyclopentanemethanol

C13H28O5SSi

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

PROCEDURE

实验过程

A suspension of (1S,3S,4S)-3-[(benzyloxy)methyl]-4-{[tert-butyl(dimethyl)silyl]-oxy}cyclopentyl methanesulfonate (690 mg, 0.0017 mol) and Palladium hydroxide, 20 wt. % Pd on carbon (160 mg, 0.00012 mol) in methanol (10 mL, 0.2 mol) was stirred under an atmosphere of hydrogen for 2 hours. The reaction was purged with nitrogen and filtered the mixture through celite with DCM. The filtrate was concentrated to obtain 350 mg (65%).

WORKUP

后处理

  1. customThe reaction was purged with nitrogen
  2. filtrationfiltered the mixture through celite with DCM
  3. concentrationThe filtrate was concentrated
  4. customto obtain 350 mg (65%)