Trifluoroacetic acid → HCID 58629078, compound

HRID 1678072Notes

Reaction equation

HRID 1678072 reaction equation
FC(F)(F)C(O)=O.[O:8]=[C:9]([CH3:28])[CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)=[CH:14][CH:13]=1>C(Cl)Cl>[NH2:20][CH2:19][CH2:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:9]([CH3:28])=[O:8])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67310057Tert-butyl 2-[4-(2-oxopropoxy)phenyl]ethylcarbamate

Product 1

HCID 58629078HCID 58629078, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step 2 Trifluoroacetic acid (0.56 mL, 7.3 mmol) was added to a solution of tert-butyl 2-[4-(2-oxopropoxy)phenyl]ethylcarbamate (216 mg, 0.74 mmol) in CH2Cl2 (4 mL). The reaction mixture was stirred for 3 hr at ambient temperature, and then reaction mixture was stripped of volatiles in vacuo. The residue (143 mg) was used without further purification.

Workup

  1. customreaction mixture
  2. customThe residue (143 mg) was used without further purification

Sources & evidence

ORD record
ord-54d63711d7c34320824bf4bbf16b9e8e
Source dataset
uspto-grants-2011_08
Patent number
US08008487B2

Reaction notes

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