HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Phenylalanine → Dopamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Phenylalanine | HCID 6140 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 2-Aminooctanoic acid | HCID 69522 | — |
| Reactant | (S)-2-amino-4-phenylbutanoic acid | HCID 2724505 | — |
| Reactant | (S)-2-(Cyclohexylamino)propanoic acid | HCID 12003067 | — |
| Reactant | N-Naphthalen-2-yl-L-alanine | HCID 18605878 | — |
| Product | Dopamine | HCID 681 | — |
Reaction Steps
Product characterization: Reverse phase HPLC: linear gradient from 15 to 65% MeCN in 15 minutes using a Symmetry C18 column (150×4.6 mm×5 μm, 100 Å, Waters), compound 6a tr: 7.83 min, compound 6b tr: 9.36 min, compound 6c tr: 9.61 min, compound 6d tr: 11.75 min, compound 6e tr: 7.85 min, compound 6f tr: 10.58 min. (Confirmed by HPLC-MS). Mass spectrometry (HPLC-MS): compound 6a: 516.5 Da, compound 6b: 522.5 Da, compound 6c: 566.2 Da, compound 6d: 640.4 Da, compound 6e: 530.3 Da, compound 6f: 510.4 Da. Yield (after purification): compound 6a: 10.8%, compound 6b: 7.2%, compound 6c: 10.9%, compound 6d: 9.6%, compound 6e: 9.1%, compound 6f: 8.2%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008492B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-5ae56b2cc7c24bcf9cd73f502be7a16d |
| Source note | uspto-grants-2011_08 |