反应详情

Product characterization: Reverse phase HPLC: linear gradient from 15 to 65% MeCN in 15 minutes using a Symmetry C18 column (150×4.6 mm×5 μm, 100 Å, Waters), compound 6a tr: 7.83 min, compound 6b tr: 9.36 min, compound 6c tr: 9.61 min, compound 6d tr: 11.75 min, compound 6e tr: 7.85 min, compound 6f tr: 10.58 min. (Confirmed by HPLC-MS). Mass spectrometry (HPLC-MS): compound 6a: 516.5 Da, compound 6b: 522.5 Da, compound 6c: 566.2 Da, compound 6d: 640.4 Da, compound 6e: 530.3 Da, compound 6f: 510.4 Da. Yield (after purification): compound 6a: 10.8%, compound 6b: 7.2%, compound 6c: 10.9%, compound 6d: 9.6%, compound 6e: 9.1%, compound 6f: 8.2%.

1. custom10.58 min. (Confirmed by HPLC-MS)
2. customYield
3. custom(after purification)