Hydrochloric Acid → 4-[7-(Azetidin-3-yloxy)-quinazolin-4-yl]-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:17]([CH3:18])([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][CH:27]([c:30]2[n:31][cH:32][n:33][c:34]3[cH:35][c:36]([F:40])[cH:37][cH:38][c:39]23)[CH2:28][CH2:29]1.[CH3:13][S:14]([CH3:15])=[O:16].[CH3:7][C:8]([CH3:9])([O-:10])[CH3:11].[ClH:1].[K+:12].[NH:2]1[CH2:3][CH:4]([OH:6])[CH2:5]1.[OH2:41]>>[NH:2]1[CH2:3][CH:4]([O:6][c:36]2[cH:35][c:34]3[n:33][cH:32][n:31][c:30]([CH:27]4[CH2:26][CH2:25][N:24]([C:22]([O:21][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:23])[CH2:29][CH2:28]4)[c:39]3[cH:38][cH:37]2)[CH2:5]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-5912f2f976264e6ca0ee7723da0b8d04
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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