Piperazine → 2-(piperazin-1-yl)-1-methyl-1H-indole-3-carboxaldehyde

HRID 1678122Notes

Reaction equation

HRID 1678122 reaction equation
Cl[C:2]1[N:3]([CH3:13])[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[N:14]1([C:2]2[N:3]([CH3:13])[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 3147922-Chloro-1-methyl-1H-indole-3-carbaldehyde

Product 1

HCID 597547452-(piperazin-1-yl)-1-methyl-1H-indole-3-carboxaldehydeYield 24%

Procedure

2-Chloro-1-methyl-1H-indole-3-carboxaldehyde (1.0 g, 5.5 mmol) is reacted with piperazine as described in Example 2 to yield the title compound (24%) as an orange-brown solid. MS 244 (M+H).

Sources & evidence

ORD record
ord-93dac44cd1834ea6809ab26a3a7315f1
Source dataset
uspto-grants-2011_08
Patent number
US08008491B2

Reaction notes

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