Piperazine → HCID 59754749, compound

HRID 1678191Notes

Reaction equation

HRID 1678191 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][OH:20])[CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[OH:20][CH2:19][C:15]1[CH:14]=[C:13]([N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:10]([CH:11]=[O:12])=[C:2]2[N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86035939HCID 86035939, compound

Product 1

HCID 59754749HCID 59754749, compoundYield 32%

Procedure

2-Chloro-1-(3-hydroxymethylphenyl)-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Step 2 of Example 29 to afford 1-(3-hydroxymethylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde (32% yield) as a red solid. ESI/MS 336 (M+H); RT=2.37 min.

Sources & evidence

ORD record
ord-d6671ac9b7224ca6a38264af07745db3
Source dataset
uspto-grants-2011_08
Patent number
US08008491B2

Reaction notes

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