Benzyl isocyanate → HCID 178522836, compound

HRID 1678232Notes

Reaction equation

HRID 1678232 reaction equation
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([NH2:21])[CH:19]=2)[NH:14][N:13]=1>C1COCC1>[CH2:1]([NH:8][C:9]([NH:21][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[I:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 178507363HCID 178507363, compound

Product 1

HCID 178522836HCID 178522836, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Benzyl isocyanate (0.25 mL, 2.0 mmol) was added to 3-iodo-1H-indazol-5-ylamine (Preparation #28, 0.50 g, 1.9 mmol) in THF (10 mL). After stirring at ambient temperature for about 2.5 hours, the mixture was filtered and washed with Et2O to give 1-benzyl-3-(3-iodo-1H-indazol-5-yl)-urea (0.41 g, 55%) as an ivory solid; RP-HPLC (Table 1, Method e) Rt 0.98 min, m/z (ESI+) 393.0 (M+H)+.

Workup

  1. filtrationthe mixture was filtered
  2. washwashed with Et2O

Sources & evidence

ORD record
ord-718f388c50334422b14119d6760ae26f
Source dataset
uspto-grants-2011_08
Patent number
US08008481B2

Reaction notes

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