Hydrogen Bromide → 2-Bromo-1-(4-chlorophenyl)propan-1-one

HRID 1678400Notes

Reaction equation

HRID 1678400 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[BrH:12].BrBr>C(O)(=O)C>[Br:12][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[O:11]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 226974'-ChloropropiophenoneHCID 24408Bromine

Product 1

HCID 37882192-Bromo-1-(4-chlorophenyl)propan-1-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 10.12 g of 4′-chloropropiophenone, 0.1 ml of hydrobromic acid (48% aqueous solution) and 60 ml of acetic acid was added 3.1 ml of bromine at 0° C. under a nitrogen atmosphere, and stirred at room temperature for 1 hour. Thereafter, the reaction mixture was concentrated under reduced pressure, to obtain 14.34 g of 2-bromo-4′-chloropropiophenone.

Workup

  1. concentrationThereafter, the reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d08b53e8a56c48769140192005f80a07
Source dataset
uspto-grants-2011_08
Patent number
US08008512B2

Reaction notes

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