Hydrazine hydrate (1:1) → HCID 57793906, compound

HRID 1678401Notes

Reaction equation

HRID 1678401 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](O)([CH3:13])[O:11][C:10](=O)[C:9]=2[C:16]2[C:21]([F:22])=[CH:20][C:19]([F:23])=[CH:18][C:17]=2[F:24])=[CH:4][CH:3]=1.O.[NH2:26][NH2:27]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH3:13])=[N:27][NH:26][C:10](=[O:11])[C:9]=2[C:16]2[C:21]([F:22])=[CH:20][C:19]([F:23])=[CH:18][C:17]=2[F:24])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 57793897HCID 57793897, compound

Product 1

HCID 57793906HCID 57793906, compoundYield 41.5%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
90 °C

Procedure

17.03 g of 4-(4-chlorophenyl)-5-hydroxy-5-methyl-3-(2,4,6-trifluorophenyl)-2(5H)-furanone, 2.64 g of hydrazine monohydrate and 240 ml of 1-butanol were mixed, and stirred at 90° C. for 3 hours. Then, the reaction mixture was cooled to 0° C. The resulting solid was collected by filtration. The collected solid was washed using hexane and t-butyl methyl ether, and dried under reduced pressure to obtain 6.99 g of 5-(4-chlorophenyl)-6-methyl-4-(2,4,6-trifluorophenyl)-2H-pyridazin-3-one.

Workup

  1. temperatureThen, the reaction mixture was cooled to 0° C
  2. filtrationThe resulting solid was collected by filtration
  3. washThe collected solid was washed
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-8b2a58fc1dc24252929976e66c0bdcb3
Source dataset
uspto-grants-2011_08
Patent number
US08008512B2

Reaction notes

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