HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1678411Generated: October 25, 2026
Sodium Hydroxide → 1-[4-chloro-6-(methylamino)-1,3,5-triazin-2-yl]-N-{[-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide
https://huagongshe.com/reaction/1678411
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine | HCID 312201 | — |
| Reactant | N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide | HCID 59614575 | — |
| Product | 1-[4-chloro-6-(methylamino)-1,3,5-triazin-2-yl]-N-{[-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide | HCID 86644312 | — |
Reaction Steps
N-{[2-(Trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (464 mg, 1.63 mmol, 1.00 equiv) was added to the suspension prepared in step b. The resulting mixture was heated to 40° C. and treated with 1 N NaOH to maintain a pH of 9-10. The reaction mixture was stirred for 2 h and then used immediately in the next step without workup or purification. MS (ES+): m/e 428.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08008483B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-35ca18e7b8e34ebdb2631e01f38b11be |
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| Source note | uspto-grants-2011_08 |
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