2,4-Dichloro-1,3,5-triazine → HCID 86644313, compound

HRID 1678419Notes

Reaction equation

HRID 1678419 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:12].[Cl:21][C:22]1[N:27]=[C:26](Cl)[N:25]=[CH:24][N:23]=1.C(N(C(C)C)CC)(C)C>C(#N)C>[Cl:21][C:22]1[N:27]=[CH:26][N:25]=[C:24]([N:16]2[CH2:17][CH2:18][CH:13]([C:11]([NH:10][CH2:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:1])([F:19])[F:20])=[O:12])[CH2:14][CH2:15]2)[N:23]=1

Participants

5

Reactant 3

HCID 178102,4-Dichloro-1,3,5-triazineHCID 81531DiisopropylethylamineHCID 59614575N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Product 1

HCID 86644313HCID 86644313, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide (315 mg, 1.10 mmol, 1.10 equiv) in acetonitrile (5 ml) at room temperature, 2,4-dichloro-1,3,5-triazine (150 mg, 1.00 mmol, 1.00 equiv) and diisopropylethylamine (DIEA, 0.875 ml, 5.00 mmol, 5.00 equiv) were added. The reaction mixture was stirred for 3 h at room temperature. Without workup or purification, the reaction was carried forward to the next step. MS (ES+): m/e 401.8 [M+H]+

Workup

  1. customWithout workup or purification

Sources & evidence

ORD record
ord-383ac8a986e243d0bdd9b5d59c04cc06
Source dataset
uspto-grants-2011_08
Patent number
US08008483B2

Reaction notes

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