HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1678422Generated: October 26, 2026
Sodium Hydroxide → 1-[4-chloro-6-(4-methyl-1-piperazinyl)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide
https://huagongshe.com/reaction/1678422
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1-(4,6-dichloro-1,3,5-triazin-2-yl)-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide | HCID 86644315 | — |
| Product | 1-[4-chloro-6-(4-methyl-1-piperazinyl)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide | HCID 86644314 | — |
Reaction Steps
N-Methylpiperazine (0.31 mL, 2.7 mmol, 1.0 equiv) was added to the suspension prepared in step a. The resulting mixture was heated to 40° C. and treated with 1 N NaOH to maintain a pH of 9-10. The reaction mixture was stirred for 30 min and then used immediately in the next step without workup or purification. MS (ES+): m/e 498.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08008483B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-dc5afbd0b1ee4562acff9d60edd1ebef |
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| Source note | uspto-grants-2011_08 |
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