HCID 59822342, compound → HCID 59822379, compound

Participants

Reaction Steps

3′-(4-Morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester (850 mg) in THF (12 ml) and 1M NaOH (25 m) was heated to 100° C. for 3 hours then cooled to room temperature. THF was evaporated and the residue extracted with dichloromethane. The aqueous layer was acidified to pH 1 and a grey solid precipitated which was collected by filtration and dried (793 mg)

Provenance & Evidence