HCID 59822342, compound → HCID 59822379, compound

HRID 1678454Notes

Reaction equation

HRID 1678454 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18](=[O:32])[NH:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[CH:22][CH:21]=3)[CH:13]=2)=[CH:8][CH:7]=1)=[O:5])C>C1COCC1.[OH-].[Na+]>[N:26]1([C:23]2[CH:24]=[CH:25][C:20]([NH:19][C:18]([C:14]3[CH:13]=[C:12]([C:9]4[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=4)[CH:17]=[CH:16][CH:15]=3)=[O:32])=[CH:21][CH:22]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1

Participants

4

Reactant 1

HCID 59822342HCID 59822342, compound

Product 1

HCID 59822379HCID 59822379, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 14798Sodium HydroxideSolvent

Procedure

3′-(4-Morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester (850 mg) in THF (12 ml) and 1M NaOH (25 m) was heated to 100° C. for 3 hours then cooled to room temperature. THF was evaporated and the residue extracted with dichloromethane. The aqueous layer was acidified to pH 1 and a grey solid precipitated which was collected by filtration and dried (793 mg)

Workup

  1. customTHF was evaporated
  2. extractionthe residue extracted with dichloromethane
  3. customa grey solid precipitated which
  4. filtrationwas collected by filtration
  5. customdried (793 mg)

Sources & evidence

ORD record
ord-6aeaecada79c47f893a9e57615a4231d
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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