2'-Methyl-5'-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid ethyl ester → 2'-Methyl-5'-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid

Participants

Reaction Steps

2′-Methyl-5′-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid ethyl ester (2.4 g) was stirred in a mixture of THF (25 ml) and 1M sodium hydroxide (50 ml) at 10° C. for 4 h. The mixture was allowed to cool and the THF was evaporated. The residue was acidified and the resultant colourless precipitate collected by filtration and dried (1.98 g).

Provenance & Evidence