反应详情

2′-Methyl-5′-(4-morpholin-4-yl-benzoylamino)-biphenyl-4-carboxylic acid ethyl ester (2.4 g) was stirred in a mixture of THF (25 ml) and 1M sodium hydroxide (50 ml) at 10° C. for 4 h. The mixture was allowed to cool and the THF was evaporated. The residue was acidified and the resultant colourless precipitate collected by filtration and dried (1.98 g).

1. temperatureto cool
2. customthe THF was evaporated
3. filtrationthe resultant colourless precipitate collected by filtration
4. customdried (1.98 g)