Sodium Hydroxide → 4-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid

HRID 1678463Notes

Reaction equation

HRID 1678463 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:15]=[CH:14][C:13]=2[CH3:26])=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:22]([O:21][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([CH3:26])=[C:12]([C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:11][CH:10]=2)[CH:17]=1)=[O:20])([CH3:25])([CH3:24])[CH3:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 598223705'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-4-carboxylic acid ethyl ester

Product 1

HCID 598223484-[5-(Tert-butoxycarbonylamino)-2-methyl-phenyl]benzoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5′-tert-Butoxycarbonylamino-2′-methyl-biphenyl-4-carboxylic acid ethyl ester (6.3 g) was stirred in ethanol (75 ml) and 1M sodium hydroxide (30 ml) at 20 C for 18 h. The mixture was then acidified and the ethanol evaporated. The pale beige solid thus formed was collected by filtration and dried (4.26 g)

Workup

  1. customthe ethanol evaporated
  2. customThe pale beige solid thus formed
  3. filtrationwas collected by filtration
  4. customdried (4.26 g)

Sources & evidence

ORD record
ord-b7aedf9efb6847d9a24fb4e5dd7c8d98
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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